Granzyme B (GraB) Autonomously Crosses the Cell Membrane and Perforin Initiates Apoptosis and GraB Nuclear Localization

Por Shi, Lianfa, Mai, Sabine, Israels, Sara, Browne, Kylie, Trapani, Joseph A., Greenberg, Arnold H.
Publicado em 1997

Efficient adenoviral infection with IκBα reveals that macrophage tumor necrosis factor α production in rheumatoid arthritis is NF-κB dependent

Por Foxwell, Brian, Browne, Kylie, Bondeson, Jan, Clarke, Chris, de Martin, Rainer, Brennan, Fionula, Feldmann, Marc
Publicado em 1998

Cytosolic Delivery of Granzyme B by Bacterial Toxins: Evidence that Endosomal Disruption, in Addition to Transmembrane Pore Formation, Is an Important Function of Perforin

Por Browne, Kylie A., Blink, Elizabeth, Sutton, Vivien R., Froelich, Christopher J., Jans, David A., Trapani, Joseph A.
Publicado em 1999

Ligation of the cell surface receptor, CD46, alters T cell polarity and response to antigen presentation

Por Oliaro, Jane, Pasam, Anupama, Waterhouse, Nigel J., Browne, Kylie A., Ludford-Menting, Mandy J., Trapani, Joseph A., Russell, Sarah M.
Publicado em 2006

Residual active granzyme B in cathepsin C–null lymphocytes is sufficient for perforin-dependent target cell apoptosis

Por Sutton, Vivien R., Waterhouse, Nigel J., Browne, Kylie A., Sedelies, Karin, Ciccone, Annette, Anthony, Desiree, Koskinen, Aulikki, Mullbacher, Arno, Trapani, Joseph A.
Publicado em 2007

Initiation of Apoptosis by Granzyme B Requires Direct Cleavage of Bid, but Not Direct Granzyme B–Mediated Caspase Activation

Por Sutton, Vivien R., Davis, Joanne E., Cancilla, Michael, Johnstone, Ricky W., Ruefli, Astrid A., Sedelies, Karin, Browne, Kylie A., Trapani, Joseph A.
Publicado em 2000

A clathrin/dynamin- and mannose-6-phosphate receptor–independent pathway for granzyme B–induced cell death

Por Trapani, Joseph A., Sutton, Vivien R., Thia, Kevin Y.T., Li, Yu Qin, Froelich, Christopher J., Jans, David A., Sandrin, Mauro S., Browne, Kylie A.
Publicado em 2003

Diarylthiophenes as inhibitors of the pore-forming protein perforin

Por Miller, Christian K., Huttunen, Kristiina M., Denny, William A., Jaiswal, Jagdish K., Ciccone, Annette, Browne, Kylie A., Trapani, Joseph A., Spicer, Julie A.
Publicado no Bioorg Med Chem Lett (2016)

The Functional Basis for Hemophagocytic Lymphohistiocytosis in a Patient with Co-inherited Missense Mutations in the Perforin (PFN1) Gene

Por Voskoboinik, Ilia, Thia, Marie-Claude, De Bono, Annette, Browne, Kylie, Cretney, Erika, Jackson, Jacob T., Darcy, Phillip K., Jane, Stephen M., Smyth, Mark J., Trapani, Joseph A.
Publicado em 2004

Benzenesulphonamide inhibitors of the cytolytic protein perforin

Por Spicer, Julie A., Miller, Christian K., O'Connor, Patrick D., Jose, Jiney, Huttunen, Kristiina M., Jaiswal, Jagdish K., Denny, William A., Akhlaghi, Hedieh, Browne, Kylie A., Trapani, Joseph A.
Publicado no Bioorg Med Chem Lett (2017)

Human perforin mutations and susceptibility to multiple primary cancers

Por Trapani, Joseph A., Thia, Kevin Y.T., Andrews, Miles, Davis, Ian D., Gedye, Craig, Parente, Philip, Svobodova, Suzanne, Chia, Jenny, Browne, Kylie, Campbell, Ian G., Phillips, Wayne A., Voskoboinik, Ilia, Cebon, Jonathan S.
Publicado em 2013

Exploration of a Series of 5-Arylidene-2-thioxoimidazolidin-4-ones as Inhibitors of the Cytolytic Protein Perforin

Por Spicer, Julie A., Lena, Gersande, Lyons, Dani M., Huttunen, Kristiina M., Miller, Christian K., O’Connor, Patrick D., Bull, Matthew, Helsby, Nuala, Jamieson, Stephen M. F., Denny, William A., Ciccone, Annette, Browne, Kylie A., Lopez, Jamie A., Rudd-Schmidt, Jesse, Voskoboinik, Ilia, Trapani, Joseph A.
Publicado em 2013