Cytosolic Delivery of Granzyme B by Bacterial Toxins: Evidence that Endosomal Disruption, in Addition to Transmembrane Pore Formation, Is an Important Function of Perforin

Granule-mediated cell killing by cytotoxic lymphocytes requires the combined actions of a membranolytic protein, perforin, and granule-associated granzymes, but the mechanism by which they jointly kill cells is poorly understood. We have tested a series of membrane-disruptive agents including bacter...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Browne, Kylie A., Blink, Elizabeth, Sutton, Vivien R., Froelich, Christopher J., Jans, David A., Trapani, Joseph A.
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Microbiology 1999
الموضوعات:
Cell Growth and Development
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC84991/
https://ncbi.nlm.nih.gov/pubmed/10567584
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