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Cytosolic Delivery of Granzyme B by Bacterial Toxins: Evidence that Endosomal Disruption, in Addition to Transmembrane Pore Formation, Is an Important Function of Perforin

Granule-mediated cell killing by cytotoxic lymphocytes requires the combined actions of a membranolytic protein, perforin, and granule-associated granzymes, but the mechanism by which they jointly kill cells is poorly understood. We have tested a series of membrane-disruptive agents including bacter...

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Main Authors: Browne, Kylie A., Blink, Elizabeth, Sutton, Vivien R., Froelich, Christopher J., Jans, David A., Trapani, Joseph A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 1999
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC84991/
https://ncbi.nlm.nih.gov/pubmed/10567584
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