Perforin pores in the endosomal membrane trigger release of endocytosed granzyme B to the cytosol of target cells

How the pore-forming protein perforin delivers apoptosis-inducing granzymes to the cytosol of target cells is uncertain. Perforin induces a transient Ca(2+) flux in the target, which triggers a damaged cell membrane repair process. As a consequence, both perforin and granzymes are endocytosed into e...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Thiery, Jerome, Keefe, Dennis, Boulant, Steeve, Boucrot, Emmanuel, Walch, Michael, Martinvalet, Denis, Goping, Ing Swie, Bleackley, R. Chris, Kirchhausen, Tomas, Lieberman, Judy
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3140544/
https://ncbi.nlm.nih.gov/pubmed/21685908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2050
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky