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Perforin pores in the endosomal membrane trigger release of endocytosed granzyme B to the cytosol of target cells
How the pore-forming protein perforin delivers apoptosis-inducing granzymes to the cytosol of target cells is uncertain. Perforin induces a transient Ca(2+) flux in the target, which triggers a damaged cell membrane repair process. As a consequence, both perforin and granzymes are endocytosed into e...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3140544/ https://ncbi.nlm.nih.gov/pubmed/21685908 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2050 |
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