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Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis

Cytotoxic T lymphocytes and natural killer cells destroy target cells via the polarized exocytosis of lytic effector proteins, perforin and granzymes, into the immunologic synapse. How these molecules enter target cells is not fully understood. It is debated whether granzymes enter via perforin pore...

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Detalhes bibliográficos
Principais autores: Thiery, Jerome, Keefe, Dennis, Saffarian, Saviz, Martinvalet, Denis, Walch, Michael, Boucrot, Emmanuel, Kirchhausen, Tomas, Lieberman, Judy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830763/
https://ncbi.nlm.nih.gov/pubmed/20038786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-10-246116
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