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Benzenesulphonamide inhibitors of the cytolytic protein perforin
The pore-forming protein perforin is a key component of mammalian cell-mediated immunity and essential to the pathway that allows elimination of virus-infected and transformed cells. Perforin activity has also been implicated in certain auto-immune conditions and therapy-induced conditions such as a...
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| Publié dans: | Bioorg Med Chem Lett |
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| Auteurs principaux: | , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Elsevier Science Ltd
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5303009/ https://ncbi.nlm.nih.gov/pubmed/28110869 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.12.057 |
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