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Missense mutations in the perforin (PRF1) gene as a cause of hereditary cancer predisposition
Perforin, a pore-forming toxin released from secretory granules of NK cells and CTLs, is essential for their cytotoxic activity against infected or cancerous target cells. Bi-allelic loss-of-function mutations in the perforin gene are invariably associated with a fatal immunoregulatory disorder, fam...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Oncoimmunology |
|---|---|
| Κύριοι συγγραφείς: | , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Taylor & Francis
2016
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5006901/ https://ncbi.nlm.nih.gov/pubmed/27622035 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1179415 |
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