Regulation of perforin activation and pre‐synaptic toxicity through C‐terminal glycosylation

Perforin is a highly cytotoxic pore‐forming protein essential for immune surveillance by cytotoxic lymphocytes. Prior to delivery to target cells by exocytosis, perforin is stored in acidic secretory granules where it remains functionally inert. However, how cytotoxic lymphocytes remain protected fr...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: House, Imran G, House, Colin M, Brennan, Amelia J, Gilan, Omer, Dawson, Mark A, Whisstock, James C, Law, Ruby HP, Trapani, Joseph A, Voskoboinik, Ilia
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5623865/
https://ncbi.nlm.nih.gov/pubmed/28808112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201744351
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