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Structural Basis for Ca(2+)-mediated Interaction of the Perforin C2 Domain with Lipid Membranes
Natural killer cells and cytotoxic T-lymphocytes deploy perforin and granzymes to kill infected host cells. Perforin, secreted by immune cells, binds target membranes to form pores that deliver pro-apoptotic granzymes into the target cell. A crucial first step in this process is interaction of its C...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4646173/ https://ncbi.nlm.nih.gov/pubmed/26306037 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.668384 |
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