Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin

The pore forming, Ca(2+)-dependent protein, perforin, is essential for the function of cytotoxic lymphocytes, which are at the frontline of immune defence against pathogens and cancer. Perforin is a glycoprotein stored in the secretory granules prior to release into the immune synapse. Congenital pe...

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發表在:Cell Death Differ
Main Authors: Brennan, Amelia J., Law, Ruby H. P., Conroy, Paul J., Noori, Tahereh, Lukoyanova, Natalya, Saibil, Helen, Yagita, Hideo, Ciccone, Annette, Verschoor, Sandra, Whisstock, James C., Trapani, Joseph A., Voskoboinik, Ilia
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2018
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6113324/
https://ncbi.nlm.nih.gov/pubmed/29416110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0057-z
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