Regulation of perforin activation and pre‐synaptic toxicity through C‐terminal glycosylation

Perforin is a highly cytotoxic pore‐forming protein essential for immune surveillance by cytotoxic lymphocytes. Prior to delivery to target cells by exocytosis, perforin is stored in acidic secretory granules where it remains functionally inert. However, how cytotoxic lymphocytes remain protected fr...

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Bibliographische Detailangaben
Veröffentlicht in:EMBO Rep
Hauptverfasser: House, Imran G, House, Colin M, Brennan, Amelia J, Gilan, Omer, Dawson, Mark A, Whisstock, James C, Law, Ruby HP, Trapani, Joseph A, Voskoboinik, Ilia
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
Schlagworte:
Scientific Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5623865/
https://ncbi.nlm.nih.gov/pubmed/28808112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201744351
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