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Discovery of Potent and Selective BRD4 Inhibitors Capable of Blocking TLR3-Induced Acute Airway Inflammation

A series of diverse small molecules have been designed and synthesized through structure-based drug design by taking advantage of fragment merging and elaboration approaches. Compounds ZL0420 (28) and ZL0454 (35) were identified as potent and selective BRD4 inhibitors with nanomolar binding affiniti...

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Bibliografiske detaljer
Udgivet i:Eur J Med Chem
Main Authors: Liu, Zhiqing, Tian, Bing, Chen, Haiying, Wang, Pingyuan, Brasier, Allan R., Zhou, Jia
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5924617/
https://ncbi.nlm.nih.gov/pubmed/29649741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.04.006
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