Selective Molecular Antagonists of the Bronchiolar Epithelial NFκB-Bromodomain-Containing Protein 4 (BRD4) Pathway in Viral-induced Airway Inflammation

The mechanisms how the mammalian airway detects invading viral pathogens to trigger protective innate neutrophilic inflammation are incompletely understood. We observe that innate activation of the NFκB/RelA transcription factor indirectly activates atypical BRD4 histone acetyltransferase (HAT) acti...

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Bibliografiset tiedot
Julkaisussa:Cell Rep
Päätekijät: Tian, Bing, Liu, Zhiqing, Yang, Jun, Sun, Hong, Zhao, Yingxin, Wakamiya, Maki, Chen, Haiying, Rytting, Erik, Zhou, Jia, Brasier, Allan R
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2018
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6020052/
https://ncbi.nlm.nih.gov/pubmed/29694891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.03.106
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