A structural insight into the P1-S1 binding mode of diaminoethylphosphonic and phosphinic acids, selective inhibitors of alanine aminopeptidases

N'-substituted 1,2-diaminoethylphosphonic acids and 1,2-diaminoethylphosphinic dipeptides were explored to unveil the structural context of the unexpected selectivity of these inhibitors of M1 alanine aminopeptidases (APNs) versus M17 leucine aminopeptidase (LAP). The diaminophosphonic acids we...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Węglarz-Tomczak, Ewelina, Berlicki, Łukasz, Pawełczak, Małgorzata, Nocek, Bogusław, Joachimiak, Andrzej, Mucha, Artur
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867306/
https://ncbi.nlm.nih.gov/pubmed/27100031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2016.04.018
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