Structure-Guided, Single-Point Modifications in the Phosphinic Dipeptide Structure Yield Highly Potent and Selective Inhibitors of Neutral Aminopeptidases

[Image: see text] Seven crystal structures of alanyl aminopeptidase from Neisseria meningitides (the etiological agent of meningitis, NmAPN) complexed with organophosphorus compounds were resolved to determine the optimal inhibitor–enzyme interactions. The enantiomeric phosphonic acid analogs of Leu...

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Vydáno v:J Med Chem
Hlavní autoři: Vassiliou, Stamatia, Węglarz-Tomczak, Ewelina, Berlicki, Łukasz, Pawełczak, Małgorzata, Nocek, Bogusław, Mulligan, Rory, Joachimiak, Andrzej, Mucha, Artur
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2014
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4331105/
https://ncbi.nlm.nih.gov/pubmed/25192493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501071f
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