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P1′ Residue-Oriented Virtual Screening for Potent and Selective Phosphinic (Dehydro) Dipeptide Inhibitors of Metallo-Aminopeptidases

Designing side chain substituents complementary to enzyme binding pockets is of great importance in the construction of potent and selective phosphinic dipeptide inhibitors of metallo-aminopeptidases. Proper structure selection makes inhibitor construction more economic, as the development process t...

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Detalhes bibliográficos
Publicado no:Biomolecules
Main Authors: Talma, Michał, Mucha, Artur
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7225938/
https://ncbi.nlm.nih.gov/pubmed/32344658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10040659
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