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Structure-Guided, Single-Point Modifications in the Phosphinic Dipeptide Structure Yield Highly Potent and Selective Inhibitors of Neutral Aminopeptidases
[Image: see text] Seven crystal structures of alanyl aminopeptidase from Neisseria meningitides (the etiological agent of meningitis, NmAPN) complexed with organophosphorus compounds were resolved to determine the optimal inhibitor–enzyme interactions. The enantiomeric phosphonic acid analogs of Leu...
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| Gepubliceerd in: | J Med Chem |
|---|---|
| Hoofdauteurs: | , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Chemical
Society
2014
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| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4331105/ https://ncbi.nlm.nih.gov/pubmed/25192493 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501071f |
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