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δ(1)-Pyrroline-5-carboxylate reductase as a new target for therapeutics: inhibition of the enzyme from Streptococcus pyogenes and effects in vivo
Compounds able to interfere with amino acid biosynthesis have the potential to inhibit cell growth. In both prokaryotic and eukaryotic microorganisms, unless an ornithine cyclodeaminase is present, the activity of δ(1)-pyrroline-5-carboxylate (P5C) reductase is mandatory to proline production, and t...
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| Asıl Yazarlar: | , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2011
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3836680/ https://ncbi.nlm.nih.gov/pubmed/21744012 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00726-011-0970-7 |
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