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δ(1)-Pyrroline-5-carboxylate reductase as a new target for therapeutics: inhibition of the enzyme from Streptococcus pyogenes and effects in vivo

Compounds able to interfere with amino acid biosynthesis have the potential to inhibit cell growth. In both prokaryotic and eukaryotic microorganisms, unless an ornithine cyclodeaminase is present, the activity of δ(1)-pyrroline-5-carboxylate (P5C) reductase is mandatory to proline production, and t...

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書誌詳細
主要な著者: Forlani, Giuseppe, Petrollino, Davide, Fusetti, Massimo, Romanini, Letizia, Nocek, Bogusław, Joachimiak, Andrzej, Berlicki, Łukasz, Kafarski, Paweł
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836680/
https://ncbi.nlm.nih.gov/pubmed/21744012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00726-011-0970-7
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