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δ(1)-Pyrroline-5-carboxylate reductase as a new target for therapeutics: inhibition of the enzyme from Streptococcus pyogenes and effects in vivo

Compounds able to interfere with amino acid biosynthesis have the potential to inhibit cell growth. In both prokaryotic and eukaryotic microorganisms, unless an ornithine cyclodeaminase is present, the activity of δ(1)-pyrroline-5-carboxylate (P5C) reductase is mandatory to proline production, and t...

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Hlavní autoři: Forlani, Giuseppe, Petrollino, Davide, Fusetti, Massimo, Romanini, Letizia, Nocek, Bogusław, Joachimiak, Andrzej, Berlicki, Łukasz, Kafarski, Paweł
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836680/
https://ncbi.nlm.nih.gov/pubmed/21744012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00726-011-0970-7
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