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Multifunctional Thiosemicarbazones and Deconstructed Analogues as a Strategy to Study the Involvement of Metal Chelation, Sigma-2 (σ(2)) Receptor and P-gp Protein in the Cytotoxic Action: in vitro and in vivo Activity in Pancreatic Tumors
The aggressiveness of pancreatic cancer urgently requires more efficient treatment options. Because the sigma-2 (σ(2)) receptor was recently proposed as a promising target for pancreatic cancer therapy, we explored our previously developed multifunctional thiosemicarbazones, designed to synergistica...
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| Publicado no: | Eur J Med Chem |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5801006/ https://ncbi.nlm.nih.gov/pubmed/29287249 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2017.12.024 |
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