Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer

BACKGROUND: Despite considerable efforts by scientific research, pancreatic cancer is the fourth leading cause of cancer related mortalities. Sigma-2 receptors, which are overexpressed in several tumors, represent promising targets for triggering selective pancreatic cancer cells death. METHODS: We...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Pati, Maria Laura, Hornick, John R., Niso, Mauro, Berardi, Francesco, Spitzer, Dirk, Abate, Carmen, Hawkins, William
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5237291/
https://ncbi.nlm.nih.gov/pubmed/28086830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-3040-4
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