Development of Inhibitors of Receptor Protein Tyrosine Phosphatase β/ζ (PTPRZ1) as Candidates for CNS disorders

A new series of blood-brain barrier permeable molecules designed to mimic the activity of Pleiotrophin in the CNS has been designed and synthesized. These compounds exert their action by interacting with the intracellular domain PD1 of the Protein Tyrosine-Phosphatase Receptor Z1 (PTPRZ1), and inhib...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Pastor, Miryam, Fernández-Calle, Rosalía, Di Geronimo, Bruno, Vicente-Rodríguez, Marta, Zapico, José María, Gramage, Esther, Coderch, Claire, Pérez-García, Carmen, Lasek, Amy W., Puchades-Carrasco, Leonor, Pineda-Lucena, Antonio, de Pascual-Teresa, Beatriz, Herradón, Gonzalo, Ramos, Ana
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5817915/
https://ncbi.nlm.nih.gov/pubmed/29275231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2017.11.080
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