Synthesis and biological evaluations of chalcones, flavones and chromenes as farnesoid x receptor (FXR) antagonists

Por Zhang, Guoning, Liu, Shuainan, Tan, Wenjuan, Verma, Ruchi, Chen, Yuan, Sun, Deyang, Huan, Yi, Jiang, Qian, Wang, Xing, Wang, Na, Xu, Yang, Wong, Chiwai, Shen, Zhufang, Deng, Ruitang, Liu, Jinsong, Zhang, Yanqiao, Fang, Weishuo
Publicado no Eur J Med Chem (2017)

Synthesis and evaluation of 6-([(11)C]methyl(4-(pyridin-2-yl)thiazol-2-yl)amino)benzo[d]thiazol-2(3H)-one for imaging γ-8 dependent transmembrane AMPA receptor regulatory protein b...

Por Yu, Qingzhen, Kumata, Katsushi, Li, Hua, Zhang, Yiding, Chen, Zhen, Zhang, Xiaofei, Shao, Tuo, Hatori, Akiko, Yamasaki, Tomoteru, Xie, Lin, Hu, Kuan, Wang, Gangqiang, Josephson, Lee, Sun, Shaofa, Zhang, Ming-Rong, Liang, Steven H.
Publicado no Bioorg Med Chem Lett (2019)

(7-Benzyloxy-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic Acids as S1P(1) Functional Antagonists

Por Buzard, Daniel J., Lopez, Luis, Moody, Jeanne, Kawasaki, Andrew, Schrader, Thomas O., Kasem, Michelle, Johnson, Ben, Zhu, Xiuwen, Thoresen, Lars, Kim, Sun Hee, Gharbaoui, Tawfik, Sengupta, Dipanjan, Calvano, Lorene, Krishnan, Ashwin, Gao, Yinghong, Semple, Graeme, Edwards, Jeff, Barden, Jeremy, Morgan, Michael, Usmani, Khawja, Chen, Chuan, Sadeque, Abu, Chen, Weichao, Christopher, Ronald J., Thatte, Jayant, Fu, Lixia, Solomon, Michelle, Whelan, Kevin, Al-Shamma, Hussien, Gatlin, Joel, Gaidarov, Ibragim, Anthony, Todd, Le, Minh, Unett, David J., Stirn, Scott, Blackburn, Anthony, Behan, Dominic P., Jones, Robert M.
Publicado no ACS Med Chem Lett (2014)

A Potent and Selective AMPK Activator That Inhibits de Novo Lipogenesis

Por Gómez-Galeno, Jorge E., Dang, Qun, Nguyen, Thanh H., Boyer, Serge H., Grote, Matthew P., Sun, Zhili, Chen, Mingwei, Craigo, William A., van Poelje, Paul D., MacKenna, Deidre A., Cable, Edward E., Rolzin, Paul A., Finn, Patricia D., Chi, Bert, Linemeyer, David L., Hecker, Scott J., Erion, Mark D.
Publicado em 2010

Design, Synthesis and Biological Evaluation of New Generation Taxoids

Por Ojima, Iwao, Chen, Jin, Sun, Liang, Borella, Christopher P., Wang, Tao, Miller, Michael L., Lin, Songnian, Geng, Xudong, Kuznetsova, Larisa, Qu, Chuanxing, Gallager, David, Zhao, Xianrui, Zanardi, Ilaria, Xia, Shujun, Horwitz, Susan B., Clair, Jon Mallen-St., Guerriero, Jennifer L., Bar-Sagi, Dafna, Veith, Jean M., Pera, Paula, Bernacki, Ralph J.
Publicado em 2008

Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor

Por Buzard, Daniel J., Kim, Sun Hee, Lopez, Luis, Kawasaki, Andrew, Zhu, Xiuwen, Moody, Jeanne, Thoresen, Lars, Calderon, Imelda, Ullman, Brett, Han, Sangdon, Lehmann, Juerg, Gharbaoui, Tawfik, Sengupta, Dipanjan, Calvano, Lorene, Montalban, Antonio Garrido, Ma, You-An, Sage, Carleton, Gao, Yinghong, Semple, Graeme, Edwards, Jeff, Barden, Jeremy, Morgan, Michael, Chen, Weichao, Usmani, Khawja, Chen, Chuan, Sadeque, Abu, Christopher, Ronald J., Thatte, Jayant, Fu, Lixia, Solomon, Michelle, Mills, David, Whelan, Kevin, Al-Shamma, Hussien, Gatlin, Joel, Le, Minh, Gaidarov, Ibragim, Anthony, Todd, Unett, David J., Blackburn, Anthony, Rueter, Jaimie, Stirn, Scott, Behan, Dominic P., Jones, Robert M.
Publicado no ACS Med Chem Lett (2014)

Identification of Imidazo[1,2-b]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors

Por Liu, Chunjian, Lin, James, Moslin, Ryan, Tokarski, John S., Muckelbauer, Jodi, Chang, ChiehYing, Tredup, Jeffrey, Xie, Dianlin, Park, Hyunsoo, Li, Peng, Wu, Dauh-Rurng, Strnad, Joann, Zupa-Fernandez, Adriana, Cheng, Lihong, Chaudhry, Charu, Chen, Jing, Chen, Cliff, Sun, Huadong, Elzinga, Paul, D’arienzo, Celia, Gillooly, Kathleen, Taylor, Tracy L., McIntyre, Kim W., Salter-Cid, Luisa, Lombardo, Louis J., Carter, Percy H., Aranibar, Nelly, Burke, James R., Weinstein, David S.
Publicado no ACS Med Chem Lett (2019)

Design, synthesis, and evaluation of novel heteroaromatic analogs of curcumin as anti-cancer agents

Por Samaan, Nawras, Zhong, Qiu, Fernandez, Jayjoel, Chen, Guanglin, Hussain, Ali M., Zheng, Shilong, Wang, Guangdi, Chen, Qiao-Hong
Publicado no Eur J Med Chem (2014)

Synthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1α Inhibition

Por Kwon, Do-Yeon, Lee, Hye Eun, Weitzel, Douglas H., Park, Kyunghye, Lee, Sun Hee, Lee, Chen-Ting, Stephenson, Tesia N., Park, Hyeri, Fitzgerald, Michael C., Chi, Jen-Tsan, Mook, Robert A., Dewhirst, Mark W., Lee, You Mie, Hong, Jiyong
Publicado no J Med Chem (2015)

Design, Synthesis, and Mechanism Study of Benzenesulfonamide-containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities

Por Sun, Lin, Dick, Alexej, Meuser, Megan E., Huang, Tianguang, Zalloum, Waleed A., Chen, Chin-Ho, Cherukupalli, Srinivasulu, Xu, Shujing, Ding, Xiao, Gao, Ping, Kang, Dongwei, De Clercq, Erik, Pannecouque, Christophe, Cocklin, Simon, Lee, Kuo-Hsiung, Liu, Xinyong, Zhan, Peng
Publicado no J Med Chem (2020)

A review on recent developments of indole-containing antiviral agents

Por Zhang, Ming-Zhi, Chen, Qiong, Yang, Guang-Fu
Publicado no Eur J Med Chem (2015)

Asymmetric 1,5-Diarylpenta-1,4-dien-3-ones: Antiproliferative Activity in Prostate Epithelial Cell Models and Pharmacokinetic Studies

Por Zhang, Xiaojie, Guo, Shanchun, Chen, Chengsheng, Perez, German Ruiz, Zhang, Changde, Patanapongpibul, Manee, Subrahmanyam, Nithya, Wang, Rubing, Keith, Joshua, Chen, Guanglin, Dong, Yan, Zhang, Qiang, Zhong, Qiu, Zheng, Shilong, Wang, Guangdi, Chen, Qiao-Hong
Publicado no Eur J Med Chem (2017)

Discovery and structural optimization of 3-O-β-chacotriosyl oleanane-type triterpenoids as potent entry inhibitors of SARS-CoV-2 virus infections

Por Li, Hui, Cheng, Chen, Li, Sumei, Wu, Yan, Liu, Zhihao, Liu, Mingjian, Chen, Jianxin, Zhong, Qiuyu, Zhang, Xuesha, Liu, Shuwen, Song, Gaopeng
Publicado no Eur J Med Chem (2021)

Synthesis and SAR study of modulators inhibiting tRXRα-dependent AKT activation

Por Wang, Zhi-Gang, Chen, Liqun, Chen, Jiebo, Zheng, Jian-Feng, Gao, Weiwei, Zeng, Zhiping, Zhou, Hu, Zhang, Xiao-kun, Huang, Pei-Qiang, Su, Ying
Publicado em 2013

Structure-activity relationship study of 4EGI-1, small molecule eIF4E/eIF4G protein-protein interaction inhibitors

Por Takrouri, Khuloud, Chen, Ting, Papadopoulos, Evangelos, Sahoo, Rupam, Kabha, Eihab, Chen, Han, Cantel, Sonia, Wagner, Gerhard, Halperin, Jose A, Aktas, Bertal H, Chorev, Michael
Publicado em 2014

Novel pH-Sensitive Cationic Lipids with Linear Ortho Ester Linkers for Gene Delivery

Por Chen, Haigang, Zhang, Huizhen, Thor, Der, Rahimian, Roshanak, Guo, Xin
Publicado em 2012

Design, synthesis, and molecular hybrids of caudatin and cinnamic acids as novel anti-hepatitis B virus agents

Por Wang, Li-Jun, Geng, Chang-An, Ma, Yun-Bao, Luo, Jie, Huang, Xiao-Yan, Chen, Hao, Zhou, Ning-Jia, Zhang, Xue-Mei, Chen, Ji-Jun
Publicado no Eur J Med Chem (2012)

Structure-Activity Relationship and Pharmacokinetic Studies of 3-O-Substitutedflavonols as Anti-Prostate Cancer Agents

Por Li, Xiang, Zhang, Changde, Guo, Shanchun, Rajaram, Pravien, Lee, Maizie, Chen, Guanglin, Fong, Ryan, Gonzalez, Aaron, Zhang, Qiang, Zheng, Shilong, Wang, Guangdi, Chen, Qiao-Hong
Publicado no Eur J Med Chem (2018)

Development of CINPA1 analogs as novel and potent inverse agonists of constitutive androstane receptor

Por Lin, Wenwei, Yang, Lei, Chai, Sergio C., Lu, Yan, Chen, Taosheng
Publicado no Eur J Med Chem (2015)

Optimization of the first small-molecule relaxin/insulin-like family peptide receptor (RXFP1) agonists: Activation results in an antifibrotic gene expression profile

Por Wilson, Kenneth J., Xiao, Jingbo, Chen, Catherine Z., Huang, Zaohua, Agoulnik, Irina U., Ferrer, Marc, Southall, Noel, Hu, Xin, Zheng, Wei, Xu, Xin, Wang, Amy, Myhr, Courtney, Barnaeva, Elena, George, Emmett R., Agoulnik, Alexander I., Marugan, Juan J.
Publicado no Eur J Med Chem (2018)