Synthesis and biological evaluations of chalcones, flavones and chromenes as farnesoid x receptor (FXR) antagonists

Farnesoid X receptor (FXR), a nuclear receptor mainly distributed in liver and intestine, has been regarded as a potential target for the treatment of various metabolic diseases, cancer and infectious diseases related to liver. Starting from two previously identified chalcone-based FXR antagonists,...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Zhang, Guoning, Liu, Shuainan, Tan, Wenjuan, Verma, Ruchi, Chen, Yuan, Sun, Deyang, Huan, Yi, Jiang, Qian, Wang, Xing, Wang, Na, Xu, Yang, Wong, Chiwai, Shen, Zhufang, Deng, Ruitang, Liu, Jinsong, Zhang, Yanqiao, Fang, Weishuo
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5505628/
https://ncbi.nlm.nih.gov/pubmed/28235703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2017.02.037
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