The eIF2-alpha kinase HRI: a potential target beyond the red blood cell

nork Burwick, Nicholas, Aktas, Bertal H.
Argitaratua izan da Expert Opin Ther Targets (2017)

Depletion of eIF2.GTP.Met-tRNA(i) translation initiation complex up-regulates BRCA1 expression in vitro and in vivo

nork Aktas, Bertal H., Bordelois, Paula, Peker, Selen, Merajver, Sophia, Halperin, Jose A.
Argitaratua izan da Oncotarget (2015)

The Best for the Most Important: Maintaining a Pristine Proteome in Stem and Progenitor Cells

nork Aktas, Bertal H., Upcin, Berin, Henke, Erik, Padmasekar, Manju, Qin, Xuebin, Ergün, Süleyman
Argitaratua izan da Stem Cells Int (2019)

In Vitro inhibition of translation initiation by N,N’-diarylureas – Potential anti-cancer agents

nork Denoyelle, Séverine, Chen, Ting, Chen, Limo, Wang, Yibo, Klosi, Edvin, Halperin, José, Aktas, Bertal H., Chorev, Michael
Argitaratua 2011

Embryonic Lethal Abnormal Vision-like HuR-dependent mRNA Stability Regulates Post-transcriptional Expression of Cyclin-dependent Kinase Inhibitor p27(Kip1)

nork Ziegeler, Gudrun, Ming, Jie, Koseki, Jana C., Sevinc, Sema, Chen, Ting, Ergun, Suleyman, Qin, Xuebin, Aktas, Bertal H.
Argitaratua 2010

3-Substituted Indazoles as Configurationally Locked 4EGI-1 Mimetic and Inhibitors of eIF4E/eIF4G Interaction

nork Yefidoff-Freedman, Revital, Chen, Ting, Sahoo, Rupam, Chen, Limo, Wagner, Gerhard, Halperin, Jose A., Aktas, Bertal H., Chorev, Michael
Argitaratua izan da Chembiochem (2014)

Small-molecule targeting of translation initiation for cancer therapy

nork Aktas, Bertal H., Qiao, Yuan, Ozdelen, Esra, Schubert, Roland, Sevinc, Sema, Harbinski, Fred, Grubissich, Luciano, Singer, Samuel, Halperin, Jose A.
Argitaratua 2013

Dual activators of Protein Kinase R (PKR) and Protein Kinase R Like Kinase (PERK) Identify Common and Divergent Catalytic Targets

nork Bai, Huijun, Chen, Ting, Ming, Jie, Sun, Hong, Cao, Peng, Fusco, Dahlene N., Chung, Raymond T., Chorev, Michael, Jin, Qi, Aktas, Bertal H.
Argitaratua 2013

Synthesis of Rigidified eIF4E/eIF4G Inhibitor-1 (4EGI-1) Mimetic and Their in Vitro Characterization as Inhibitors of Protein–Protein Interaction

nork Mahalingam, Poornachandran, Takrouri, Khuloud, Chen, Ting, Sahoo, Rupam, Papadopoulos, Evangelos, Chen, Limo, Wagner, Gerhard, Aktas, Bertal H., Halperin, Jose A., Chorev, Michael
Argitaratua 2014

Structure-activity relationship study of 4EGI-1, small molecule eIF4E/eIF4G protein-protein interaction inhibitors

nork Takrouri, Khuloud, Chen, Ting, Papadopoulos, Evangelos, Sahoo, Rupam, Kabha, Eihab, Chen, Han, Cantel, Sonia, Wagner, Gerhard, Halperin, Jose A, Aktas, Bertal H, Chorev, Michael
Argitaratua 2014

Explorations of Substituted Urea Functionality for Discovery of New Activators of the Heme Regulated Inhibitor Kinase

nork Chen, Ting, Takrouri, Khuloud, Hee-Hwang, Sung, Rana, Sandeep, Yefidoff-Freedman, Revital, Halperin, Jose, Natarajan, Amarnath, Morisseau, Christophe, Hammock, Bruce, Chorev, Michael, Aktas, Bertal H.
Argitaratua 2013

Human CD59 inhibitor sensitizes rituximab resistant lymphoma cells to complement-mediated cytolysis

nork Hu, Weiguo, Ge, Xiaowen, You, Tao, Xu, Ting, Zhang, Jinyan, Wu, Gongxiong, Peng, Zhihai, Chorev, Michael, Aktas, Bertal H., Halperin, Jose A., Brown, Jennifer R, Qin, Xuebin
Argitaratua 2011

Chemical Genetics Identify eIF2α Kinase Heme Regulated Inhibitor as Anti-Cancer Target

nork Chen, Ting, Ozel, Duygu, Qiao, Yuan, Harbinski, Fred, Chen, Limo, Denoyelle, Séverine, He, Xiaoying, Zvereva, Nela, Supko, Jeffrey G., Chorev, Michael, Halperin, Jose A., Aktas, Bertal H.
Argitaratua 2011

Tumor suppression by small molecule inhibitors of translation initiation

nork Chen, Limo, Aktas, Bertal H, Wang, Yibo, He, Xiaoying, Sahoo, Rupam, Zhang, Nancy, Denoyelle, Severine, Kabha, Eihab, Yang, Hongwei, Freedman, Revital Yefidoff, Supko, Jeffrey G, Chorev, Michael, Wagner, Gerhard, Halperin, Jose A
Argitaratua 2012

Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G

nork Papadopoulos, Evangelos, Jenni, Simon, Kabha, Eihab, Takrouri, Khuloud J., Yi, Tingfang, Salvi, Nicola, Luna, Rafael E., Gavathiotis, Evripidis, Mahalingam, Poornachandran, Arthanari, Haribabu, Rodriguez-Mias, Ricard, Yefidoff-Freedman, Revital, Aktas, Bertal H., Chorev, Michael, Halperin, Jose A., Wagner, Gerhard
Argitaratua 2014

Emerging Role for the PERK/eIF2α/ATF4 in Human Cutaneous Leishmaniasis

nork Dias-Teixeira, Karina Luiza, Calegari-Silva, Teresa C., Medina, Jorge M., Vivarini, Áislan C., Cavalcanti, Átila, Teteo, Nataly, Santana, Alynne Karen M., Real, Fernando, Gomes, Ciro M., Pereira, Renata Meirelles Santos, Fasel, Nicolas, Silva, João S., Aktas, Bertal H., Lopes, Ulisses G.
Argitaratua izan da Sci Rep (2017)

Development of 1-((1,4-trans)-4-aryloxycyclohexyl)-3-arylurea Activators of the Heme Regulated Inhibitor as Selective Activators of Eukaryotic Initiation Factor 2 alpha (eIF2α) Pho...

nork Yefidoff-Freedman, Revital, Fan, Jing, Yan, Lu, Zhang, Quingwen, dos Santos, Guillermo Rodrigo Reis, Rana, Sandeep, Contreras, Jacob I., Sahoo, Rupam, Wang, Debin, Young, Jun, Teixeira, Karina Luisa Dias, Morisseau, Christophe, Halperin, Jose, Hammock, Bruce, Natarajan, Amarnath, Wang, Peimin, Chorev, Michael, Aktas, Bertal H.
Argitaratua izan da J Med Chem (2017)

SARS-CoV-2 Infects Endothelial Cells In Vivo and In Vitro

nork Liu, Fengming, Han, Kun, Blair, Robert, Kenst, Kornelia, Qin, Zhongnan, Upcin, Berin, Wörsdörfer, Philipp, Midkiff, Cecily C., Mudd, Joseph, Belyaeva, Elizaveta, Milligan, Nicholas S., Rorison, Tyler D., Wagner, Nicole, Bodem, Jochen, Dölken, Lars, Aktas, Bertal H., Vander Heide, Richard S., Yin, Xiao-Ming, Kolls, Jay K., Roy, Chad J., Rappaport, Jay, Ergün, Süleyman, Qin, Xuebin
Argitaratua izan da Front Cell Infect Microbiol (2021)

Endothelial cell infection and dysfunction, immune activation in severe COVID-19

nork Qin, Zhongnan, Liu, Fengming, Blair, Robert, Wang, Chenxiao, Yang, Haoran, Mudd, Joseph, Currey, Joshua M, Iwanaga, Naoki, He, Jibao, Mi, Ren, Han, Kun, Midkiff, Cecily C., Alam, Mohammad Afaque, Aktas, Bertal H, Heide, Richard S Vander, Veazey, Ronald, Piedimonte, Giovanni, Maness, Nicholas J, Ergün, Süleyman, Mauvais-Jarvis, Franck, Rappaport, Jay, Kolls, Jay K., Qin, Xuebin
Argitaratua izan da Theranostics (2021)

Distinct fate, dynamics and niches of renal macrophages of bone marrow or embryonic origins

nork Liu, Fengming, Dai, Shen, Feng, Dechun, Qin, Zhongnan, Peng, Xiao, Sakamuri, Siva S. V. P., Ren, Mi, Huang, Li, Cheng, Min, Mohammad, Kabir E., Qu, Ping, Chen, Yong, Zhao, Chunling, Zhu, Faliang, Liang, Shujian, Aktas, Bertal H., Yang, Xiaofeng, Wang, Hong, Katakam, Prasad V. G., Busija, David W., Fischer, Tracy, Datta, Prasun K., Rappaport, Jay, Gao, Bin, Qin, Xuebin
Argitaratua izan da Nat Commun (2020)