Structure-activity relationship study of 4EGI-1, small molecule eIF4E/eIF4G protein-protein interaction inhibitors

Protein-protein interactions are critical for regulating the activity of translation initiation factors and multitude of other cellular process, and form the largest block of untapped albeit most challenging targets for drug development. 4EGI-1, (E/Z)-2-(2-(4-(3,4-dichlorophenyl)thiazol-2-yl)hydrazo...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Takrouri, Khuloud, Chen, Ting, Papadopoulos, Evangelos, Sahoo, Rupam, Kabha, Eihab, Chen, Han, Cantel, Sonia, Wagner, Gerhard, Halperin, Jose A, Aktas, Bertal H, Chorev, Michael
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2014
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128255/
https://ncbi.nlm.nih.gov/pubmed/24675136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2014.03.034
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