Molecular mechanism of the dual activity of 4EGI-1: Dissociating eIF4G from eIF4E but stabilizing the binding of unphosphorylated 4E-BP1

The eIF4E-binding protein (4E-BP) is a phosphorylation-dependent regulator of protein synthesis. The nonphosphorylated or minimally phosphorylated form binds translation initiation factor 4E (eIF4E), preventing binding of eIF4G and the recruitment of the small ribosomal subunit. Signaling events sti...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Sekiyama, Naotaka, Arthanari, Haribabu, Papadopoulos, Evangelos, Rodriguez-Mias, Ricard A., Wagner, Gerhard, Léger-Abraham, Mélissa
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522750/
https://ncbi.nlm.nih.gov/pubmed/26170285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1512118112
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