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The Role of Dynamics and Allostery in the Inhibition of the eIF4E/eIF4G Translation Initiation Factor Complex
Lack of regulation of the eIF4E/eIF4G interaction is a hallmark of cancer. 4EGI-1 binds to eIF4E preventing association to eIF4G via an allosteric mechanism. We use NMR spectroscopy and MD simulations to obtain a mechanistic description of the role of correlated dynamics in this allosteric regulatio...
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| Publicado no: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5022372/ https://ncbi.nlm.nih.gov/pubmed/27162083 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201603254 |
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