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The Role of Dynamics and Allostery in the Inhibition of the eIF4E/eIF4G Translation Initiation Factor Complex
Lack of regulation of the eIF4E/eIF4G interaction is a hallmark of cancer. 4EGI-1 binds to eIF4E preventing association to eIF4G via an allosteric mechanism. We use NMR spectroscopy and MD simulations to obtain a mechanistic description of the role of correlated dynamics in this allosteric regulatio...
Gorde:
| Argitaratua izan da: | Angew Chem Int Ed Engl |
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| Egile Nagusiak: | , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2016
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5022372/ https://ncbi.nlm.nih.gov/pubmed/27162083 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201603254 |
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