Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation

The RNA helicase eIF4A plays a key role in unwinding of mRNA and scanning during translation initiation. Free eIF4A is a poor helicase and requires the accessory proteins eIF4G and eIF4H. However, the structure of the helicase complex and the mechanisms of stimulation of eIF4A activity have remained...

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Detalhes bibliográficos
Main Authors: Marintchev, Assen, Edmonds, Katherine A., Marintcheva, Boriana, Hendrickson, Elthea, Oberer, Monika, Suzuki, Chikako, Herdy, Barbara, Sonenberg, Nahum, Wagner, Gerhard
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2656774/
https://ncbi.nlm.nih.gov/pubmed/19203580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.01.014
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