PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains

Programmed Cell Death 4 (PDCD4) is a protein known to bind eukaryotic initiation factor 4A (eIF4A), inhibit translation initiation, and act as a tumor suppressor. PDCD4 contains two C-terminal MA3 domains, which are thought to be responsible for its inhibitory function. Here, we analyze the structur...

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Main Authors: Suzuki, Chikako, Garces, Robert G., Edmonds, Katherine A., Hiller, Sebastian, Hyberts, Sven G., Marintchev, Assen, Wagner, Gerhard
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2008
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265113/
https://ncbi.nlm.nih.gov/pubmed/18296639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0712235105
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