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PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains
Programmed Cell Death 4 (PDCD4) is a protein known to bind eukaryotic initiation factor 4A (eIF4A), inhibit translation initiation, and act as a tumor suppressor. PDCD4 contains two C-terminal MA3 domains, which are thought to be responsible for its inhibitory function. Here, we analyze the structur...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2265113/ https://ncbi.nlm.nih.gov/pubmed/18296639 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0712235105 |
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