Dynamic Interaction of Eukaryotic Initiation Factor 4G1 (eIF4G1) with eIF4E and eIF1 Underlies Scanning-Dependent and -Independent Translation

Translation initiation of most mRNAs involves m7G-cap binding, ribosomal scanning, and AUG selection. Initiation from an m7G-cap-proximal AUG can be bypassed resulting in leaky scanning, except for mRNAs bearing the translation initiator of short 5′ untranslated region (TISU) element. m7G-cap bindin...

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Publicado no:Mol Cell Biol
Main Authors: Haimov, Ora, Sehrawat, Urmila, Tamarkin-Ben Harush, Ana, Bahat, Anat, Uzonyi, Anna, Will, Alexander, Hiraishi, Hiroyuki, Asano, Katsura, Dikstein, Rivka
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6113598/
https://ncbi.nlm.nih.gov/pubmed/29987188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00139-18
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