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Synthesis of Rigidified eIF4E/eIF4G Inhibitor-1 (4EGI-1) Mimetic and Their in Vitro Characterization as Inhibitors of Protein–Protein Interaction
[Image: see text] The 4EGI-1 is the prototypic inhibitor of eIF4E/eIF4G interaction, a potent inhibitor of translation initiation in vitro and in vivo and an efficacious anticancer agent in animal models of human cancers. We report on the design, synthesis, and in vitro characterization of a series...
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| Main Authors: | , , , , , , , , , |
|---|---|
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
American Chemical
Society
2014
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| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4216204/ https://ncbi.nlm.nih.gov/pubmed/24827861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401733v |
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