The eIF2-alpha kinase HRI: a potential target beyond the red blood cell

بواسطة Burwick, Nicholas, Aktas, Bertal H.
الحاوية / القاعدة Expert Opin Ther Targets (2017)

Depletion of eIF2.GTP.Met-tRNA(i) translation initiation complex up-regulates BRCA1 expression in vitro and in vivo

بواسطة Aktas, Bertal H., Bordelois, Paula, Peker, Selen, Merajver, Sophia, Halperin, Jose A.
الحاوية / القاعدة Oncotarget (2015)

The Best for the Most Important: Maintaining a Pristine Proteome in Stem and Progenitor Cells

بواسطة Aktas, Bertal H., Upcin, Berin, Henke, Erik, Padmasekar, Manju, Qin, Xuebin, Ergün, Süleyman
الحاوية / القاعدة Stem Cells Int (2019)

In Vitro inhibition of translation initiation by N,N’-diarylureas – Potential anti-cancer agents

بواسطة Denoyelle, Séverine, Chen, Ting, Chen, Limo, Wang, Yibo, Klosi, Edvin, Halperin, José, Aktas, Bertal H., Chorev, Michael
منشور في 2011

Embryonic Lethal Abnormal Vision-like HuR-dependent mRNA Stability Regulates Post-transcriptional Expression of Cyclin-dependent Kinase Inhibitor p27(Kip1)

بواسطة Ziegeler, Gudrun, Ming, Jie, Koseki, Jana C., Sevinc, Sema, Chen, Ting, Ergun, Suleyman, Qin, Xuebin, Aktas, Bertal H.
منشور في 2010

3-Substituted Indazoles as Configurationally Locked 4EGI-1 Mimetic and Inhibitors of eIF4E/eIF4G Interaction

بواسطة Yefidoff-Freedman, Revital, Chen, Ting, Sahoo, Rupam, Chen, Limo, Wagner, Gerhard, Halperin, Jose A., Aktas, Bertal H., Chorev, Michael
الحاوية / القاعدة Chembiochem (2014)

Small-molecule targeting of translation initiation for cancer therapy

بواسطة Aktas, Bertal H., Qiao, Yuan, Ozdelen, Esra, Schubert, Roland, Sevinc, Sema, Harbinski, Fred, Grubissich, Luciano, Singer, Samuel, Halperin, Jose A.
منشور في 2013

Dual activators of Protein Kinase R (PKR) and Protein Kinase R Like Kinase (PERK) Identify Common and Divergent Catalytic Targets

بواسطة Bai, Huijun, Chen, Ting, Ming, Jie, Sun, Hong, Cao, Peng, Fusco, Dahlene N., Chung, Raymond T., Chorev, Michael, Jin, Qi, Aktas, Bertal H.
منشور في 2013

Synthesis of Rigidified eIF4E/eIF4G Inhibitor-1 (4EGI-1) Mimetic and Their in Vitro Characterization as Inhibitors of Protein–Protein Interaction

بواسطة Mahalingam, Poornachandran, Takrouri, Khuloud, Chen, Ting, Sahoo, Rupam, Papadopoulos, Evangelos, Chen, Limo, Wagner, Gerhard, Aktas, Bertal H., Halperin, Jose A., Chorev, Michael
منشور في 2014

Structure-activity relationship study of 4EGI-1, small molecule eIF4E/eIF4G protein-protein interaction inhibitors

بواسطة Takrouri, Khuloud, Chen, Ting, Papadopoulos, Evangelos, Sahoo, Rupam, Kabha, Eihab, Chen, Han, Cantel, Sonia, Wagner, Gerhard, Halperin, Jose A, Aktas, Bertal H, Chorev, Michael
منشور في 2014

Explorations of Substituted Urea Functionality for Discovery of New Activators of the Heme Regulated Inhibitor Kinase

بواسطة Chen, Ting, Takrouri, Khuloud, Hee-Hwang, Sung, Rana, Sandeep, Yefidoff-Freedman, Revital, Halperin, Jose, Natarajan, Amarnath, Morisseau, Christophe, Hammock, Bruce, Chorev, Michael, Aktas, Bertal H.
منشور في 2013

Human CD59 inhibitor sensitizes rituximab resistant lymphoma cells to complement-mediated cytolysis

بواسطة Hu, Weiguo, Ge, Xiaowen, You, Tao, Xu, Ting, Zhang, Jinyan, Wu, Gongxiong, Peng, Zhihai, Chorev, Michael, Aktas, Bertal H., Halperin, Jose A., Brown, Jennifer R, Qin, Xuebin
منشور في 2011

Chemical Genetics Identify eIF2α Kinase Heme Regulated Inhibitor as Anti-Cancer Target

بواسطة Chen, Ting, Ozel, Duygu, Qiao, Yuan, Harbinski, Fred, Chen, Limo, Denoyelle, Séverine, He, Xiaoying, Zvereva, Nela, Supko, Jeffrey G., Chorev, Michael, Halperin, Jose A., Aktas, Bertal H.
منشور في 2011

Tumor suppression by small molecule inhibitors of translation initiation

بواسطة Chen, Limo, Aktas, Bertal H, Wang, Yibo, He, Xiaoying, Sahoo, Rupam, Zhang, Nancy, Denoyelle, Severine, Kabha, Eihab, Yang, Hongwei, Freedman, Revital Yefidoff, Supko, Jeffrey G, Chorev, Michael, Wagner, Gerhard, Halperin, Jose A
منشور في 2012

Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G

بواسطة Papadopoulos, Evangelos, Jenni, Simon, Kabha, Eihab, Takrouri, Khuloud J., Yi, Tingfang, Salvi, Nicola, Luna, Rafael E., Gavathiotis, Evripidis, Mahalingam, Poornachandran, Arthanari, Haribabu, Rodriguez-Mias, Ricard, Yefidoff-Freedman, Revital, Aktas, Bertal H., Chorev, Michael, Halperin, Jose A., Wagner, Gerhard
منشور في 2014

Emerging Role for the PERK/eIF2α/ATF4 in Human Cutaneous Leishmaniasis

بواسطة Dias-Teixeira, Karina Luiza, Calegari-Silva, Teresa C., Medina, Jorge M., Vivarini, Áislan C., Cavalcanti, Átila, Teteo, Nataly, Santana, Alynne Karen M., Real, Fernando, Gomes, Ciro M., Pereira, Renata Meirelles Santos, Fasel, Nicolas, Silva, João S., Aktas, Bertal H., Lopes, Ulisses G.
الحاوية / القاعدة Sci Rep (2017)

Development of 1-((1,4-trans)-4-aryloxycyclohexyl)-3-arylurea Activators of the Heme Regulated Inhibitor as Selective Activators of Eukaryotic Initiation Factor 2 alpha (eIF2α) Pho...

بواسطة Yefidoff-Freedman, Revital, Fan, Jing, Yan, Lu, Zhang, Quingwen, dos Santos, Guillermo Rodrigo Reis, Rana, Sandeep, Contreras, Jacob I., Sahoo, Rupam, Wang, Debin, Young, Jun, Teixeira, Karina Luisa Dias, Morisseau, Christophe, Halperin, Jose, Hammock, Bruce, Natarajan, Amarnath, Wang, Peimin, Chorev, Michael, Aktas, Bertal H.
الحاوية / القاعدة J Med Chem (2017)

SARS-CoV-2 Infects Endothelial Cells In Vivo and In Vitro

بواسطة Liu, Fengming, Han, Kun, Blair, Robert, Kenst, Kornelia, Qin, Zhongnan, Upcin, Berin, Wörsdörfer, Philipp, Midkiff, Cecily C., Mudd, Joseph, Belyaeva, Elizaveta, Milligan, Nicholas S., Rorison, Tyler D., Wagner, Nicole, Bodem, Jochen, Dölken, Lars, Aktas, Bertal H., Vander Heide, Richard S., Yin, Xiao-Ming, Kolls, Jay K., Roy, Chad J., Rappaport, Jay, Ergün, Süleyman, Qin, Xuebin
الحاوية / القاعدة Front Cell Infect Microbiol (2021)

Endothelial cell infection and dysfunction, immune activation in severe COVID-19

بواسطة Qin, Zhongnan, Liu, Fengming, Blair, Robert, Wang, Chenxiao, Yang, Haoran, Mudd, Joseph, Currey, Joshua M, Iwanaga, Naoki, He, Jibao, Mi, Ren, Han, Kun, Midkiff, Cecily C., Alam, Mohammad Afaque, Aktas, Bertal H, Heide, Richard S Vander, Veazey, Ronald, Piedimonte, Giovanni, Maness, Nicholas J, Ergün, Süleyman, Mauvais-Jarvis, Franck, Rappaport, Jay, Kolls, Jay K., Qin, Xuebin
الحاوية / القاعدة Theranostics (2021)

Distinct fate, dynamics and niches of renal macrophages of bone marrow or embryonic origins

بواسطة Liu, Fengming, Dai, Shen, Feng, Dechun, Qin, Zhongnan, Peng, Xiao, Sakamuri, Siva S. V. P., Ren, Mi, Huang, Li, Cheng, Min, Mohammad, Kabir E., Qu, Ping, Chen, Yong, Zhao, Chunling, Zhu, Faliang, Liang, Shujian, Aktas, Bertal H., Yang, Xiaofeng, Wang, Hong, Katakam, Prasad V. G., Busija, David W., Fischer, Tracy, Datta, Prasun K., Rappaport, Jay, Gao, Bin, Qin, Xuebin
الحاوية / القاعدة Nat Commun (2020)