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In Vitro inhibition of translation initiation by N,N’-diarylureas – Potential anti-cancer agents
Symmetrical N,N’-diarylureas: 1,3-bis(3,4-dichlorophenyl)-, 1,3-bis[4-chloro-3(trifluoromethyl) phenyl]- and 1,3-bis[3,5-bis(trifluoromethyl)phenyl]urea, were identified as potent activators of the eIF2α kinase heme regulated inhibitor. They reduce the abundance of the eIF2·GTP·tRNA(i)(Met) ternary...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3248974/ https://ncbi.nlm.nih.gov/pubmed/22153346 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.10.126 |
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