In Vitro inhibition of translation initiation by N,N’-diarylureas – Potential anti-cancer agents

Symmetrical N,N’-diarylureas: 1,3-bis(3,4-dichlorophenyl)-, 1,3-bis[4-chloro-3(trifluoromethyl) phenyl]- and 1,3-bis[3,5-bis(trifluoromethyl)phenyl]urea, were identified as potent activators of the eIF2α kinase heme regulated inhibitor. They reduce the abundance of the eIF2·GTP·tRNA(i)(Met) ternary...

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Huvudupphovsmän: Denoyelle, Séverine, Chen, Ting, Chen, Limo, Wang, Yibo, Klosi, Edvin, Halperin, José, Aktas, Bertal H., Chorev, Michael
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248974/
https://ncbi.nlm.nih.gov/pubmed/22153346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.10.126
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