Structure-activity relationship study of 4EGI-1, small molecule eIF4E/eIF4G protein-protein interaction inhibitors

Protein-protein interactions are critical for regulating the activity of translation initiation factors and multitude of other cellular process, and form the largest block of untapped albeit most challenging targets for drug development. 4EGI-1, (E/Z)-2-(2-(4-(3,4-dichlorophenyl)thiazol-2-yl)hydrazo...

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Detalhes bibliográficos
Main Authors: Takrouri, Khuloud, Chen, Ting, Papadopoulos, Evangelos, Sahoo, Rupam, Kabha, Eihab, Chen, Han, Cantel, Sonia, Wagner, Gerhard, Halperin, Jose A, Aktas, Bertal H, Chorev, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128255/
https://ncbi.nlm.nih.gov/pubmed/24675136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2014.03.034
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