Structure-activity relationship study of 4EGI-1, small molecule eIF4E/eIF4G protein-protein interaction inhibitors

Protein-protein interactions are critical for regulating the activity of translation initiation factors and multitude of other cellular process, and form the largest block of untapped albeit most challenging targets for drug development. 4EGI-1, (E/Z)-2-(2-(4-(3,4-dichlorophenyl)thiazol-2-yl)hydrazo...

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Bibliografiska uppgifter
Huvudupphovsmän: Takrouri, Khuloud, Chen, Ting, Papadopoulos, Evangelos, Sahoo, Rupam, Kabha, Eihab, Chen, Han, Cantel, Sonia, Wagner, Gerhard, Halperin, Jose A, Aktas, Bertal H, Chorev, Michael
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128255/
https://ncbi.nlm.nih.gov/pubmed/24675136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2014.03.034
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