Structure-activity relationship study of 4EGI-1, small molecule eIF4E/eIF4G protein-protein interaction inhibitors

Protein-protein interactions are critical for regulating the activity of translation initiation factors and multitude of other cellular process, and form the largest block of untapped albeit most challenging targets for drug development. 4EGI-1, (E/Z)-2-(2-(4-(3,4-dichlorophenyl)thiazol-2-yl)hydrazo...

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主要な著者: Takrouri, Khuloud, Chen, Ting, Papadopoulos, Evangelos, Sahoo, Rupam, Kabha, Eihab, Chen, Han, Cantel, Sonia, Wagner, Gerhard, Halperin, Jose A, Aktas, Bertal H, Chorev, Michael
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128255/
https://ncbi.nlm.nih.gov/pubmed/24675136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2014.03.034
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