Design, Synthesis and Biological Evaluation of New Generation Taxoids

Novel second-generation taxoids with systematic modifications at the C2, C10, and C3’N positions were synthesized and their structure-activity relationships studied. A number of these taxoids exhibited exceptionally high potentency against multidrug drug-resistant cell lines, and several taxoids exh...

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Detalhes bibliográficos
Main Authors: Ojima, Iwao, Chen, Jin, Sun, Liang, Borella, Christopher P., Wang, Tao, Miller, Michael L., Lin, Songnian, Geng, Xudong, Kuznetsova, Larisa, Qu, Chuanxing, Gallager, David, Zhao, Xianrui, Zanardi, Ilaria, Xia, Shujun, Horwitz, Susan B., Clair, Jon Mallen-St., Guerriero, Jennifer L., Bar-Sagi, Dafna, Veith, Jean M., Pera, Paula, Bernacki, Ralph J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2734907/
https://ncbi.nlm.nih.gov/pubmed/18465846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800086e
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