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Synthesis and Biological Evaluation of Novel 3′-Difluorovinyl Taxoids
A series of 3′-difluorovinyl taxoids with C10 modifications, as well as those with C2 and C10 modifications, were strategically designed to block the metabolism by cytochrome P-450 3A4 enzyme and synthesized. These novel difluorovinyl taxoids were evaluated for their cytotoxicity against drug-sensit...
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| Hauptverfasser: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3489494/ https://ncbi.nlm.nih.gov/pubmed/23139432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jfluchem.2012.07.007 |
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