Synthesis and Biological Evaluation of Novel 3′-Difluorovinyl Taxoids

A series of 3′-difluorovinyl taxoids with C10 modifications, as well as those with C2 and C10 modifications, were strategically designed to block the metabolism by cytochrome P-450 3A4 enzyme and synthesized. These novel difluorovinyl taxoids were evaluated for their cytotoxicity against drug-sensit...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kuznetsova, Larissa, Sun, Liang, Chen, Jin, Zhao, Xianrui, Seitz, Joshua, Das, Manisha, Li, Yuan, Veith, Jean M., Pera, Paula, Bernacki, Ralph J., Xia, Shujun, Horwitz, Susan B., Ojima, Iwao
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2012
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3489494/
https://ncbi.nlm.nih.gov/pubmed/23139432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jfluchem.2012.07.007
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