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Development of CINPA1 analogs as novel and potent inverse agonists of constitutive androstane receptor
Constitutive androstane receptor (CAR, NR1I3) and pregnane X receptor (PXR, NR1I2) are master regulators of endobiotic and xenobiotic metabolism and disposition. Because CAR is constitutively active in certain cellular contexts, inhibiting CAR might reduce drug-induced hepatotoxicity and resensitize...
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| Publicado no: | Eur J Med Chem |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4724233/ https://ncbi.nlm.nih.gov/pubmed/26717202 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2015.12.018 |
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