CINPA1 binds directly to constitutive androstane receptor and inhibits its activity

The constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are xenobiotic sensors that regulate the expression of drug-metabolizing enzymes and efflux transporters. CAR activation promotes drug elimination, thereby reducing therapeutic effectiveness, or causes adverse drug effects via...

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Detalhes bibliográficos
Publicado no:Biochem Pharmacol
Main Authors: Cherian, Milu T., Chai, Sergio C., Wright, William C., Singh, Aman, Casal, Morgan Alexandra, Zheng, Jie, Wu, Jing, Lee, Richard E., Griffin, Patrick R., Chen, Taosheng
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5960625/
https://ncbi.nlm.nih.gov/pubmed/29608908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2018.03.029
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