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CINPA1 Is an Inhibitor of Constitutive Androstane Receptor That Does Not Activate Pregnane X Receptor

Constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are xenobiotic sensors that enhance the detoxification and elimination of xenobiotics and endobiotics by modulating the expression of genes encoding drug-metabolizing enzymes and transporters. Elevated levels of drug-metabolizing e...

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Detalhes bibliográficos
Publicado no:Mol Pharmacol
Main Authors: Cherian, Milu T, Lin, Wenwei, Wu, Jing, Chen, Taosheng
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4407736/
https://ncbi.nlm.nih.gov/pubmed/25762023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.097782
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