Development of CINPA1 analogs as novel and potent inverse agonists of constitutive androstane receptor

Constitutive androstane receptor (CAR, NR1I3) and pregnane X receptor (PXR, NR1I2) are master regulators of endobiotic and xenobiotic metabolism and disposition. Because CAR is constitutively active in certain cellular contexts, inhibiting CAR might reduce drug-induced hepatotoxicity and resensitize...

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Veröffentlicht in:Eur J Med Chem
Hauptverfasser: Lin, Wenwei, Yang, Lei, Chai, Sergio C., Lu, Yan, Chen, Taosheng
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4724233/
https://ncbi.nlm.nih.gov/pubmed/26717202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2015.12.018
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