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Novel pH-Sensitive Cationic Lipids with Linear Ortho Ester Linkers for Gene Delivery

In an effort to develop pH-sensitive lipoplexes for efficient gene delivery, we report three novel cationic lipids containing a linear ortho ester linker that conjugates either the headgroup (Type I) or one hydrocarbon chain (Type II) with the rest of the lipid molecule. The cationic lipids carry ei...

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Bibliografische gegevens
Hoofdauteurs: Chen, Haigang, Zhang, Huizhen, Thor, Der, Rahimian, Roshanak, Guo, Xin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383799/
https://ncbi.nlm.nih.gov/pubmed/22480493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2012.03.013
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