Design, Synthesis, and Mechanism Study of Benzenesulfonamide-containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities

HIV-1 CA protein has gained remarkable attention as a promising therapeutic target for the development of new antivirals, due to its pivotal roles in HIV-1 replication (structural and regulatory). Herein, we report the design and synthesis of three series of benzenesulfonamide-containing phenylalani...

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Publicado en:J Med Chem
Main Authors: Sun, Lin, Dick, Alexej, Meuser, Megan E., Huang, Tianguang, Zalloum, Waleed A., Chen, Chin-Ho, Cherukupalli, Srinivasulu, Xu, Shujing, Ding, Xiao, Gao, Ping, Kang, Dongwei, De Clercq, Erik, Pannecouque, Christophe, Cocklin, Simon, Lee, Kuo-Hsiung, Liu, Xinyong, Zhan, Peng
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8011991/
https://ncbi.nlm.nih.gov/pubmed/32298111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00015
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