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Rapid optimization of the metabolic stability of an HIV-1 capsid inhibitor using a multistep computational workflow
The poor metabolic stability of the HIV-1 CA inhibitor PF-74 is a major concern in its development towards clinical use. To improve on the metabolic stability, we employed a novel multistep computationally driven workflow, which facilitated the rapid design of improved PF-74 analogs in an efficient...
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| 發表在: | J Med Chem |
|---|---|
| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2021
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8043142/ https://ncbi.nlm.nih.gov/pubmed/33750123 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c01810 |
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