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Computationally designed libraries for rapid enzyme stabilization
The ability to engineer enzymes and other proteins to any desired stability would have wide-ranging applications. Here, we demonstrate that computational design of a library with chemically diverse stabilizing mutations allows the engineering of drastically stabilized and fully functional variants o...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3893934/ https://ncbi.nlm.nih.gov/pubmed/24402331 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzt061 |
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